International Journal of Clinical and Experimental Medical Sciences

Volume 5, Issue 2, March 2019

  • α1-adrenergic Receptor Attenuates β1-adrenergic Modulation of IKr by Protein Kinase C-dependent Suppression of Adenylyl Cyclase in Ventricular Myocytes

    Sen Wang, Xiaoyan Wang, Jin Qian, Di Xu

    Issue: Volume 5, Issue 2, March 2019
    Pages: 26-32
    Received: 8 May 2019
    Accepted: 10 June 2019
    Published: 25 June 2019
    Abstract: The rapid delayed rectifier K+ current (Ikr) is critical for repolarization of the cardiac action potential. Previous studies have shown activated α1-adrenergic receptor (AR) attenuates β1-adrenergic regulation of Ikr while the mechanisms involved are poorly understood. To evalutate how α1-adrenergic receptor affect β1-adrenergic modulation of Ikr,... Show More
  • Impact of Laboratory Diagnostic Preanalytics on Patient Blood Management

    Kathrin Schlatterer, Kathrin Schlüter

    Issue: Volume 5, Issue 2, March 2019
    Pages: 33-40
    Received: 14 March 2019
    Accepted: 15 May 2019
    Published: 29 June 2019
    Abstract: This study was designed to investigate the possibility of reducing diagnostic blood loss as a lab-side element of Patient Blood Management. To this end, the nominal blood volume of blood collection tubes was reduced and, additionally, preanalytical processes were optimised to minimise repeated blood collections. These interventions were conducted i... Show More
  • Morphological Peculiarities of Apoptosis’ Course in Hepatic Cells

    Asomiddin Faizovich Sadriddinov, Khushvakt Beknazarov Joraevich, Muborak Asomidinovna Sadriddinova, Elena Nikolaevna Guzacheva

    Issue: Volume 5, Issue 2, March 2019
    Pages: 41-45
    Received: 19 March 2019
    Accepted: 16 May 2019
    Published: 12 July 2019
    Abstract: The course dynamics of apoptosis in hepatic cells of experimental rabbits (n = 16) and white rats (n = 18) was researched by morphological methods. In natural death (apoptosis) the hepatic cells were divided into two parts. At the first type of apoptosis the hepatocyte’s cytoplasm became clearing, the little vesicles occurred, therefore this type w... Show More