Transfusion Associated Graft Versus Host Disease: A Case Report and Review of Literature
Divya Doval,
Sanjeev K. Sharma,
Meet Kumar,
Vipin Khandelwal,
Anil Handoo,
Tina Dadu,
Dharma Choudhary
Issue:
Volume 5, Issue 3, May 2019
Pages:
46-48
Received:
28 May 2019
Accepted:
17 July 2019
Published:
7 August 2019
Abstract: Transfusion associated graft versus host disease (TA-GvHD) is a rare but usually fatal complication of transfusion of cellular blood products. It is seen usually in immunosuppressed individuals due to engraftment of viable T lymphocytes but it may also occur in immunocompetent individuals. Patients present with fever, skin rash, diarrhoea, hepatic dysfunction and bone marrow aplasia which manifests as pancytopenia. The diagnosis of TA-GvHD is often delayed because of lack of awareness due to the non-specific manifestations and often these symptoms are attributed to the underlying illness. We present here a case report of fatal TA-GvHD in an immunocompetent patient, post coronary artery bypass grafting surgery after transfusion of blood products. The patient died 27 days after a blood transfusion. An increased risk of TA-GvHD following bypass grafting and other surgical procedures where cardiopulmonary bypass is required has been perceived. TA-GvHD is under reported and the incidence is felt to be too low to warrant routine irradiation of cellular products. Physicians, surgeons and transfusion centers should be aware of this rare but devastating complication of blood transfusion so as to either diagnose it early or rather prevent it.
Abstract: Transfusion associated graft versus host disease (TA-GvHD) is a rare but usually fatal complication of transfusion of cellular blood products. It is seen usually in immunosuppressed individuals due to engraftment of viable T lymphocytes but it may also occur in immunocompetent individuals. Patients present with fever, skin rash, diarrhoea, hepatic ...
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Modeling Three-Dimensional Geometric Shapes from Nucleic Acid Sequences Using a Computerized Numerical Control
Issue:
Volume 5, Issue 3, May 2019
Pages:
49-52
Received:
14 July 2019
Accepted:
5 August 2019
Published:
16 August 2019
Abstract: The nucleic acid sequence is an astonishing and a complicated coding system that is capable of producing a complete human body with of its molecules, cells, tissue and organs. Nucleic acid has been used in many fields of sciences for the preservation and encoding of different types of information. The current project describes the use of a computerized numerical control device to form 3D geometric shapes from nucleic acid sequences. The device employs dynamic algorithms to store and then identify the strings of letters of the nucleic acid sequence, transforming them into trigonometric matrices of continues triangular codes and ultimately translating each one of matrix codes into points in 3D space to construct three-dimensional geometric shapes. This method is useful for storing architectural design and blueprints, as well as, helping to establish a standardized coding technology for 3D printing devices.
Abstract: The nucleic acid sequence is an astonishing and a complicated coding system that is capable of producing a complete human body with of its molecules, cells, tissue and organs. Nucleic acid has been used in many fields of sciences for the preservation and encoding of different types of information. The current project describes the use of a computer...
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