International Journal of Clinical and Experimental Medical Sciences

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Morphological Peculiarities of Apoptosis’ Course in Hepatic Cells

Received: 19 March 2019    Accepted: 16 May 2019    Published: 12 July 2019
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Abstract

The course dynamics of apoptosis in hepatic cells of experimental rabbits (n = 16) and white rats (n = 18) was researched by morphological methods. In natural death (apoptosis) the hepatic cells were divided into two parts. At the first type of apoptosis the hepatocyte’s cytoplasm became clearing, the little vesicles occurred, therefore this type was called as “boiling cytoplasm”. It was more often in rats. The volume of cell increased and became round, the nucleus got peaknotized, and, finally, the apoptotic bodies became formed and eliminated in sinusoids. The second type of apoptosis was characterized with homogenization and acidophilic colour of cytoplasm, the cellular nucleus was decomposed into large conglomerations and kariorexis occurred, so it was marked as “nuclear catastrophe”. At the end of both types the hepatocyte cellular membrane got ruptured, and cytoplasm’s content separated in lumen of vessel. Sometimes old, not being undergone to apoptosis “longliving” hepatocytes became separated from hepatic plates and wholly extrused in lumen of sinusoid. Conclusion: by the cytological course, depending on mainly damage of hepatocyte’ cytoplasm or nucleus two types of apoptosis were divided. Except apoptic death in the liver the extrusion display of “longliving” hepatocytes were revealed.

DOI 10.11648/j.ijcems.20190502.13
Published in International Journal of Clinical and Experimental Medical Sciences (Volume 5, Issue 2, March 2019)
Page(s) 41-45
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Liver, Morphology, Apoptosis, Hepatocyte Extrusion

References
[1] Aruin l. I. Apoptosis and pathology of liver., // Russian jornal Gastroenterology, Hepatology Coloproctology.-2008.-№2.- P. 6-10.
[2] Belushkina I. I. Molecular bases of apoptosis’ pathology., //Archives of pathology.-2001.- V. 63. №1. - P. 51-60.
[3] Zalesskiy V. N., Velikaya N. V. Apoptosis mechanisms at hepatic diseases.,// Modern problems of toxicology.- 2002. - № 4. - P. 27-32.
[4] Arber N., Zajicek G., Arnicl J. The streaming liver // Liver-2008. - P. 80-87.
[5] Benedetti A., Jezugel A. M., Oriondi F. Preferential distribution of apoptotic bodies in acinar zone 3 of normal human and rat liver // J. Hepatol.- 2012.-7. –P. 319-324.
[6] Cande C., Cecconi F., Dessen P. Apoptosis-inducing factor: key to the conserved caspase- independent pathways of cell death? // Cell Sci. 2002. - V. 115-P. 4727-4734.
[7] Ivashkin V. T., Cellular and molecular biology of liver inflammation.,// Russian journal Gastroenterology, Hepatology, Coloproctology.- 2005.- W. 15.– P. 13-17.
[8] Vinogradov A. A. Influence of doxirubicine on the apoptosis’ process in hepatic cells at experiment, // Ukrainian journal of experimental medicine.- 2008.- V. 9. №4. - P. 59-61.
[9] Kerr J. F. R., Willie A. H., Carrie A. R. Apoptosis: a basic biological phenomen with wide-ringing implications tissue kinetics // Brit. J. Cancer- 2012.-26. –P. 239-257.
[10] Colombono A., Ledda-Columbano G. M. Com G. et al. Occurrence of cell death (apoptosis) during the involution of liver hyperplasia // Lab. Invest. -2015-51.-P. 670-675.
[11] Sadriddinov A. F., Isaeva N. Z. Portovenous gradient is functional element of liver. /In mater. collect: International extra (заочная) research practical conferens “Scintific discussion: Medical questions`. Moscow, 2013, -P. 57-66.
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    Asomiddin Faizovich Sadriddinov, Khushvakt Beknazarov Joraevich, Muborak Asomidinovna Sadriddinova, Elena Nikolaevna Guzacheva. (2019). Morphological Peculiarities of Apoptosis’ Course in Hepatic Cells. International Journal of Clinical and Experimental Medical Sciences, 5(2), 41-45. https://doi.org/10.11648/j.ijcems.20190502.13

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    Asomiddin Faizovich Sadriddinov; Khushvakt Beknazarov Joraevich; Muborak Asomidinovna Sadriddinova; Elena Nikolaevna Guzacheva. Morphological Peculiarities of Apoptosis’ Course in Hepatic Cells. Int. J. Clin. Exp. Med. Sci. 2019, 5(2), 41-45. doi: 10.11648/j.ijcems.20190502.13

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    AMA Style

    Asomiddin Faizovich Sadriddinov, Khushvakt Beknazarov Joraevich, Muborak Asomidinovna Sadriddinova, Elena Nikolaevna Guzacheva. Morphological Peculiarities of Apoptosis’ Course in Hepatic Cells. Int J Clin Exp Med Sci. 2019;5(2):41-45. doi: 10.11648/j.ijcems.20190502.13

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  • @article{10.11648/j.ijcems.20190502.13,
      author = {Asomiddin Faizovich Sadriddinov and Khushvakt Beknazarov Joraevich and Muborak Asomidinovna Sadriddinova and Elena Nikolaevna Guzacheva},
      title = {Morphological Peculiarities of Apoptosis’ Course in Hepatic Cells},
      journal = {International Journal of Clinical and Experimental Medical Sciences},
      volume = {5},
      number = {2},
      pages = {41-45},
      doi = {10.11648/j.ijcems.20190502.13},
      url = {https://doi.org/10.11648/j.ijcems.20190502.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20190502.13},
      abstract = {The course dynamics of apoptosis in hepatic cells of experimental rabbits (n = 16) and white rats (n = 18) was researched by morphological methods. In natural death (apoptosis) the hepatic cells were divided into two parts. At the first type of apoptosis the hepatocyte’s cytoplasm became clearing, the little vesicles occurred, therefore this type was called as “boiling cytoplasm”. It was more often in rats. The volume of cell increased and became round, the nucleus got peaknotized, and, finally, the apoptotic bodies became formed and eliminated in sinusoids. The second type of apoptosis was characterized with homogenization and acidophilic colour of cytoplasm, the cellular nucleus was decomposed into large conglomerations and kariorexis occurred, so it was marked as “nuclear catastrophe”. At the end of both types the hepatocyte cellular membrane got ruptured, and cytoplasm’s content separated in lumen of vessel. Sometimes old, not being undergone to apoptosis “longliving” hepatocytes became separated from hepatic plates and wholly extrused in lumen of sinusoid. Conclusion: by the cytological course, depending on mainly damage of hepatocyte’ cytoplasm or nucleus two types of apoptosis were divided. Except apoptic death in the liver the extrusion display of “longliving” hepatocytes were revealed.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Morphological Peculiarities of Apoptosis’ Course in Hepatic Cells
    AU  - Asomiddin Faizovich Sadriddinov
    AU  - Khushvakt Beknazarov Joraevich
    AU  - Muborak Asomidinovna Sadriddinova
    AU  - Elena Nikolaevna Guzacheva
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    DO  - 10.11648/j.ijcems.20190502.13
    T2  - International Journal of Clinical and Experimental Medical Sciences
    JF  - International Journal of Clinical and Experimental Medical Sciences
    JO  - International Journal of Clinical and Experimental Medical Sciences
    SP  - 41
    EP  - 45
    PB  - Science Publishing Group
    SN  - 2469-8032
    UR  - https://doi.org/10.11648/j.ijcems.20190502.13
    AB  - The course dynamics of apoptosis in hepatic cells of experimental rabbits (n = 16) and white rats (n = 18) was researched by morphological methods. In natural death (apoptosis) the hepatic cells were divided into two parts. At the first type of apoptosis the hepatocyte’s cytoplasm became clearing, the little vesicles occurred, therefore this type was called as “boiling cytoplasm”. It was more often in rats. The volume of cell increased and became round, the nucleus got peaknotized, and, finally, the apoptotic bodies became formed and eliminated in sinusoids. The second type of apoptosis was characterized with homogenization and acidophilic colour of cytoplasm, the cellular nucleus was decomposed into large conglomerations and kariorexis occurred, so it was marked as “nuclear catastrophe”. At the end of both types the hepatocyte cellular membrane got ruptured, and cytoplasm’s content separated in lumen of vessel. Sometimes old, not being undergone to apoptosis “longliving” hepatocytes became separated from hepatic plates and wholly extrused in lumen of sinusoid. Conclusion: by the cytological course, depending on mainly damage of hepatocyte’ cytoplasm or nucleus two types of apoptosis were divided. Except apoptic death in the liver the extrusion display of “longliving” hepatocytes were revealed.
    VL  - 5
    IS  - 2
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Author Information
  • Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan; Department of Histology and Pathologic Anatomy, Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan

  • Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan

  • Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan

  • Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan

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