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Department of Gastroenterology, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China
Background: Primary splenic lymphoma (PSL) is a rare type of tumor that occurs in the spleen, generally without the involvement of intrasplenic organs and lymph nodes, and its incidence is less than 1% of lymphomas, most of which are non-Hodgkin's lymphomas (NHL). Diffuse large B-cell lymphoma (DL- BCL) often has atypical clinical manifestations, which makes clinical diagnosis difficult and is prone to misdiagnosis or omission, posing a significant challenge to clinical diagnosis and treatment. Colorectal cancer is the third most frequent cancer and the fourth most common cause of death in the world and is diagnosed on the basis of clinical manifestations, X-ray barium enema, or fibreoptic colonoscopy. The key to colorectal cancer treatment lies in early detection, timely diagnosis, and surgical eradication. Although lymphoma and colorectal cancer are some of the most frequent malignant tumours in adults, and there are guidelines for the diagnosis and treatment of both diseases, their co-occurrence is extremely uncommon, and there are fewer reports in the literature on the diagnosis and treatment of co-existing cases, and there is still no definitive and effective method for diagnosis, differential diagnosis and treatment. A case of splenic diffuse large B-cell lymphoma complicated with colon cancer was admitted to our hospital, and we now report its clinical data, conduct a literature review and analysis in order better to carry out clinical diagnosis, differential diagnosis and treatment, and summarize the diagnosis and comprehensive treatment experience of this disease. This case report provides ideas for the diagnosis and treatment of the disease.
Primary Splenic Lymphoma, Diffuse Large B-Cell Lymphoma, Colon Cancer
Guoqing Huang, Chulin Liang, Mingzhi Sang, Xuyou Liu. (2023). Analysis of a Case of Colon Cancer Complicated with Diffuse Large B-Cell Lymphoma of the Spleen. International Journal of Clinical and Experimental Medical Sciences, 9(5), 79-84. https://doi.org/10.11648/j.ijcems.20230905.12
Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
| 1. | Xu LL, Gu KS. Clinical retrospective analysis of cases with multiple primary malignant neoplasms. Genet Mol Res. 2014, 13(4): 9271-9284. |
| 2. | Shuangshuang Chen, Rui Ma. Research progress in multiple primary cancers [J]. Cancer Progress. 2019. 17(08): 883-886. |
| 3. | Barron BA, Localio SA. A statistical note on the association of colorectal cancer and lymphoma. Am J Epidemiol. 1976; 104(5): 517-522. |
| 4. | Srikumar T, Markow M, Centeno B, et al. Synchronous rectal adenocarcinoma and splenic marginal zone lymphoma. Curr Oncol. 2016; 23(1): e70-e74. |
| 5. | Hopster D, Smith PA, Nash JR, Elders K, Poston GJ. Synchronous multiple lymphomatous polyposis and adenocarcinomata in the large bowel. Postgrad Med J. 1995; 71(837): 443. |
| 6. | Wagle SD, Mohandas KM, Vazifdar KF, et al. Synchronous adenocarcinoma and lymphoma of the colon. Indian J Gastroenterol. 1997; 16(1): 28-2. |
| 7. | Hirano K, Yamashita K, Yamashita N, et al. Non-Hodgkin's lymphoma in a patient with probable hereditary nonpolyposis colon cancer: report of a case and review of the literature. Dis Colon Rectum. 2002; 45(2): 273-279. |
| 8. | Yunpeng Huang, Zong Zhang, Chaoting Liu, Liping Su. Clinical analysis of primary splenic lymphoma [J]. Clinical Medicine Practice, 2017, 26(12): 922-924. |
| 9. | Tseng CE, Shu TW, Lin CW, Liao KS. Synchronous adenocarcinoma and extranodal natural killer/T-cell lymphoma of the colon: a case report and literature review. World J Gastroenterol. 2013; 19(11): 1850-1854. |
| 10. | Pozo AL, Godfrey EM, Bowles KM. Splenomegaly: investigation, diagnosis and management. Blood Rev. 2009; 23(3): 105-111. |
| 11. | Görg C, Faoro C, Bert T, Tebbe J, Neesse A, Wilhelm C. Contrast enhanced ultrasound of splenic lymphoma involvement. Eur J Radiol. 2011; 80(2): 169-174. |
| 12. | Eloubeidi MA, Chen VK, Eltoum IA, et al. Endoscopic ultrasound-guided fine needle aspiration biopsy of patients with suspected pancreatic cancer: diagnostic accuracy and acute and 30-day complications. Am J Gastroenterol. 2003; 98(12): 2663-2668. |
| 13. | Dongxin Wang, Hongyong Jin, Xin Jiang, Xuanwen Liu, Zhuo Liu. A case report and literature review of splenic diffuse large B-cell lymphoma [J]. Chinese Experimental Diagnostics, 2013, 17(11): 2104-2105. |
| 14. | Maglione T, Yong S, Velankar M, Brems J. Image of the month: primary splenic high-grade lymphoma. Arch Surg. 2009; 144(7): 691-692. |
| 15. | Bennett M, Schechter GP. Treatment of splenic marginal zone lymphoma: splenectomy versus rituximab. Semin Hematol. 2010; 47(2): 143-147. |
| 16. | Yang Lu. Analysis of clinical diagnosis and surgical treatment of splenic space-occupying lesions [D]. China Medical University, 2018. |
| 17. | Pantoja Pachajoa DA, Bruno MA, Alvarez FA, Viscido G, Mandojana F, Doniquian A. Multiple primary tumors: Colorectal carcinoma and non-Hodgkin's lymphoma. Int J Surg Case Rep. 2018; 48: 92–94. |
| 18. | Grosskreutz C, Troy K, Cuttner J. Primary splenic lymphoma: report of 10 cases using the REAL classification. Cancer Invest. 2002; 20(5-6): 749-753. |
| 19. | Morel P, Dupriez B, Gosselin B, et al. Role of early splenectomy in malignant lymphomas with prominent splenic involvement (primary lymphomas of the spleen). A study of 59 cases. Cancer. 1993; 71(1): 207-215. |
