Volume 6, Issue 2, March 2020, Page: 17-24
Wavelength Effect in Laser Therapy of Diabetic Rats on Oxidants: AGEs, AOPP, ox-LDL Levels
Hossein Mirmiranpour, Endocrinology and Metabolism Research Center (EMRC), Valiasr Hospital, School of Medicine, Tehran University of Medical Science, Tehran, Iran
Ahmad Amjadi, Laser and Medical Physics Lab, Department of Physics, Sharif University of Technology, Tehran, Iran
Salile Khandani, Laser and Medical Physics Lab, Department of Physics, Sharif University of Technology, Tehran, Iran
Yasaman Shafaee, Laser and Medical Physics Lab, Department of Physics, Sharif University of Technology, Tehran, Iran
Seyed Omid Sobhani, Laser and Medical Physics Lab, Department of Physics, Sharif University of Technology, Tehran, Iran
Received: Mar. 26, 2020;       Accepted: Apr. 21, 2020;       Published: May 28, 2020
DOI: 10.11648/j.ijcems.20200602.11      View  346      Downloads  95
In Low-Level Laser Therapy (LLLT) choosing the proper laser wavelength is extremely important. In this article, we have investigated the effects of four different laser wavelengths on oxidant parameters (AGE, AOPP, and ox-LDL) levels in diabetic Wistar rats experimentally. At first, 24 rats were divided into six equal groups. Except for the none diabetic control group, the other five groups received streptozotocin (STZ) injection to induce diabetes. Four groups of diabetic rats were then irradiated by four different laser wavelengths IR (808nm), Red (638nm), Green (532nm) and Blue (450nm). The last group which did not receive any irradiation is named non-irradiated diabetic control group. Laser therapies were performed Intravenously through an animal's caudal vein by a fiber Optics. Finally, the levels of oxidant parameters in rat's blood samples of each group were discussed. Results show a decrease in oxidants levels in all four irradiated groups of rats relative to the non-irradiated diabetic control group. More importantly, shorter wavelengths affect more efficient than longer wavelengths on reducing the oxidants levels with constant Laser energy. As a result, we conclude that laser with shorter wavelength e.g. Blue is more effective than longer wavelengths e.g. IR or Red, in reducing the oxidant parameters (AGE, AOPP, and ox-LDL) levels in Intravenous LLLT.
Laser Therapy, Diabetes, Oxidants, AGEs, AOPP, Ox-LDL
To cite this article
Hossein Mirmiranpour, Ahmad Amjadi, Salile Khandani, Yasaman Shafaee, Seyed Omid Sobhani, Wavelength Effect in Laser Therapy of Diabetic Rats on Oxidants: AGEs, AOPP, ox-LDL Levels, International Journal of Clinical and Experimental Medical Sciences. Vol. 6, No. 2, 2020, pp. 17-24. doi: 10.11648/j.ijcems.20200602.11
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This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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