Volume 5, Issue 3, May 2019, Page: 46-48
Transfusion Associated Graft Versus Host Disease: A Case Report and Review of Literature
Divya Doval, Department of Hemato-oncology and Bone Marrow Transplantation, BLK Superspeciality Hospital, New Delhi, India
Sanjeev K. Sharma, Department of Hemato-oncology and Bone Marrow Transplantation, BLK Superspeciality Hospital, New Delhi, India
Meet Kumar, Department of Hemato-oncology and Bone Marrow Transplantation, BLK Superspeciality Hospital, New Delhi, India
Vipin Khandelwal, Department of Hemato-oncology and Bone Marrow Transplantation, BLK Superspeciality Hospital, New Delhi, India
Anil Handoo, Department of Hematology, BLK Superspeciality Hospital, New Delhi, India
Tina Dadu, Department of Hematology, BLK Superspeciality Hospital, New Delhi, India
Dharma Choudhary, Department of Hemato-oncology and Bone Marrow Transplantation, BLK Superspeciality Hospital, New Delhi, India
Received: May 28, 2019;       Accepted: Jul. 17, 2019;       Published: Aug. 7, 2019
DOI: 10.11648/j.ijcems.20190503.11      View  86      Downloads  16
Abstract
Transfusion associated graft versus host disease (TA-GvHD) is a rare but usually fatal complication of transfusion of cellular blood products. It is seen usually in immunosuppressed individuals due to engraftment of viable T lymphocytes but it may also occur in immunocompetent individuals. Patients present with fever, skin rash, diarrhoea, hepatic dysfunction and bone marrow aplasia which manifests as pancytopenia. The diagnosis of TA-GvHD is often delayed because of lack of awareness due to the non-specific manifestations and often these symptoms are attributed to the underlying illness. We present here a case report of fatal TA-GvHD in an immunocompetent patient, post coronary artery bypass grafting surgery after transfusion of blood products. The patient died 27 days after a blood transfusion. An increased risk of TA-GvHD following bypass grafting and other surgical procedures where cardiopulmonary bypass is required has been perceived. TA-GvHD is under reported and the incidence is felt to be too low to warrant routine irradiation of cellular products. Physicians, surgeons and transfusion centers should be aware of this rare but devastating complication of blood transfusion so as to either diagnose it early or rather prevent it.
Keywords
Transfusion Associated GvHD (TA-GvHD), Immunocompetent Host, Post CABG
To cite this article
Divya Doval, Sanjeev K. Sharma, Meet Kumar, Vipin Khandelwal, Anil Handoo, Tina Dadu, Dharma Choudhary, Transfusion Associated Graft Versus Host Disease: A Case Report and Review of Literature, International Journal of Clinical and Experimental Medical Sciences. Vol. 5, No. 3, 2019, pp. 46-48. doi: 10.11648/j.ijcems.20190503.11
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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