Volume 5, Issue 1, January 2019, Page: 5-9
Effect of Blood Transfusion on Platelet-Related Antibodies in ITP Patients
Li Meiling, The Third Affiliated Hospital of Guizhou Medical University, Duyun, China; Department of Hematology, Zhongshan Hospital Affiliated of Xiamen University, Xiamen, China
Li Long, The Third Affiliated Hospital of Guizhou Medical University, Duyun, China
Meng Fuxue, The Third Affiliated Hospital of Guizhou Medical University, Duyun, China
Received: Dec. 24, 2018;       Accepted: Jan. 22, 2019;       Published: Feb. 19, 2019
DOI: 10.11648/j.ijcems.20190501.12      View  591      Downloads  80
Objective: To detect the expression of platclet associated immunoglobulin (PAIg) on the ITP patients’ platelet surface and study the effect and correlation of blood transfusion therapy on PAIg. Methods: The 173 patients confirmed as ITP selected form the outpatients and inpatients of the Department of Hematology and Rheumatology in the Third Affiliated Hospital of Guizhou Medical University, were divided into the blood transfusion group and the non-blood transfusion group, FCM fluorescence immunolabeling was used to measure expression quantity of PAIg, the positive expression rate and fluorescence intensity of PAIgG, PAIgM and PAIgA expressed on the platelet surface of ITP patients and the control group respectively. The softwave SPSS12.0 was applied to analyze the correlation. Results: (1) PAIgG (2.96 + 8.31) %, PAIgM (2.27 + 1.78) %, PAIgA (4.48 + 3.88) % in the non-transfusion group were significantly lower than those in the transfusion group (11.44 + 20.04) %, (9.72 + 15.24) %, (10.13 + 9.53) %, P<0.001. (2) The number of platelets in the non-transfusion group was significantly negatively correlated with PAIgM, r=-0.457, P<0.05. There was no significant correlation with PAIgG and PAIgA, all P values were >0.05. Conclusion: (1) It can increase platelet antibody after blood transfusion, and patients with ITP are more likely to produce platelet antibody after blood transfusion. (2) There is a certain degree of correlation between PAIg and blood transfusion in ITP patients.
Idiopathic Thrombocytopenic Purpura, Platelet Related Antibodies, Blood Transfusion
To cite this article
Li Meiling, Li Long, Meng Fuxue, Effect of Blood Transfusion on Platelet-Related Antibodies in ITP Patients, International Journal of Clinical and Experimental Medical Sciences. Vol. 5, No. 1, 2019, pp. 5-9. doi: 10.11648/j.ijcems.20190501.12
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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